Premature menopause, or failure, ovarian, premature (POF), a disorder in which ovulation of the ovaries and menstrual periods before age 40 ends. Natural menopause at approximately age 50 years to happen. The adults called that for 12 months consecutive menstrual periods.

the prevalence of this disorder is 1% of the total population of women. Some of the causes of this problem include: defects genetic, autoimmune disorders, etc. tuberculosis (TB), genital, etc. consumption of cigarettes, chemotherapy, or radiotherapy, etc. hysterectomy is the treatment is long with GnRH and defects enzyme.