Acronym of IRS

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Internal Revenue Service (US government)

Insulin Receptor Substrate

Indoor Residual Spraying (mosquito control)

Independent Rear Suspension

Interest Rate Swap

Insulin Receptor Signaling

Indian Remote Sensing Satellite

Infrared Spectrograph

Image Retrieval System (computing)

Insulin Resistance Syndrome

Institut für Raumfahrtsysteme (German: Institute of Space Systems)

Information Retrieval System

InfoFrame Relational Store (NEC Corporation)

Indian Register of Shipping (Indian ship classification society)

Internal Rating System (finance)

Imposto Sobre o Rendimento das Pessoas Singulares (Portuguese tax)

Immune Reconstitution Syndrome

Interactive Response System (educational remote control)

Indus River System

Information Required Schedule (project planning)

Iron Replacement System (golf)

Inertial Reference System

Investment Research Service

Incident Reporting System

Interface Requirements Specification

Information Referral Services (Ontario, Canada)

Information Reporting System

Increasing Returns to Scale

Information and Referral Specialist (various organizations)

Indian Revenue Service (India)

Investor Relations Society

Interpreter Referral Service (various organizations)

International Register of Shipping (est. 1993; shipping industry)

Inventory Reduction Sale

Irwin R. Schyster (pro wrestler)

Internal Review Service (UK)

Identical, Related and Similar (US DHHS)

Improved Rain Suit (US Air Force)

International Radar Symposium

Intelligence Research Specialist (FBI)

Institute of Regional Studies (Pakistan government)

Integrated Resorts Scheme (Mauritius)

Intra Renal Surgery

Integrated Receivables Solutions (banking)

Informal Resolution System

Insurance Restoration Services, Inc. (New Jersey)

International Referral System (now INFOTERRA)

Inherited Runners Scored (baseball; runner on base who scores after a new pitcher enters)

Intel Research Seattle

International Rorschach Society

Illinois Radiological Society

Independent Recyling Services

Interest Rate Support

Infrared Locking System (automobiles)

Internationally Recruited Staff

Intermediate Reference System

International Research and Studies Program (US)

Intelligent Register System (Q.I. Press Controls)

individual replacement system (World War 2 troop rotation)

Industrial Relations Survey (UK)

Immunoreactive Remmele Score (cancer)

Information Receiving Station

Infrared Soldering

Interstate Repeater Society

Ionizing Radiation Standards Group (National Research Council of Canada, Ottawa, Canada)

I'll Return Shortly

Ignition Radiation Suppression

Interdisciplinary Research Support (various schools)

Incident Response Service

Indian Remote Sensing System

Inland Refugee Society (Vancouver, British Columbia, Canada)

Index of Retail Saturation

International Reference Star (set of star catalogs)

Interferometric Rayleigh Scattering

Item Reduction Study

Input Record Seperator (Perl programming language)

Increasing Radius Search

Imagery Requirements Structure

Individual Readiness Survey (education)

Infrastructure Requirements Specification

Interference Reduction System

Institute of Railway Signal Engineers (UK)

Infrared Suppressor

Indiana Railroad System

Indefinite Reserve Status

Induction and Recruiting Station

Institute for Reactor Safety, Germany (now Gesellschaft für Anlagen- und Reaktorsicherheit mbH)