Drug-facilitated sexual assault (DFSA) is a sexual assault (rape or otherwise) carried out on a person after the person has become incapacitated due to being under the influence of any mind-altering substances, such as having consumed alcohol or been intentionally administered another date rape drug. The rape form is also known as predator rape. 75% of all acquaintance rapes involve alcohol and/or drugs. Drugs, when used with alcohol, can result in a loss of consciousness and a loss of the ability to consent to sex.

Researchers have found that alcohol-facilitated rape is the most common form of sexual violence against women. As with other types of rape, a DFSA is a crime of physical violence, and can be a result of sexual hedonism and entitlement. Most victims of DFSA are women and perpetrators men.