Acronym of FOXP3
( Forkhead Box P3 ) Protein FOXP3 that with the name "" (Scurfin) is also known. is a protein that in response, a safety device body involved. This molecule component of the protein family, FOX and is a main regulator in the process of organizing the expression of genes in the context of the evolution and function of lymphocytes, t-regulator can be considered. Lymphocytes, t-regulator, in total they reduce the immune response. In the flow of cancer, increase the activity of the lymphocytes caused by your body's immune system fails to well with the cancer cells fight. When the incidence of disease, autoimmune disease, reducing the activity of lymphocytes, t-regulator causes other immune cells to the tissue itself in the body, attacking.
although the exact mechanism of control and regulation of these molecules has not yet determined. the protein, FOX, themselves, belong to the large family system factors, transcription spiral winged/ that are probably the same verb can increase free radicals connection used in the flow regulating transcription of a DNA. used.
in the model, system, lymphocytes, t-regulator, transcription factor FOXP3, etc. the promoter gene involved in the performance of this type of lymphocytes has occupied, and possibly after stimulation, receptors, lymphocytes, t -, thereby transcribe genes, the main and most important in this field.
the gene coding FOXP3 has 11 exons and has been on the arm of the short chromosome X (in particular, the position Xp11.23) is located.
apart the role that FOXP3 in the field of differentiation of lymphocytes, t-regulator has the evidence several of the important role of this gene and in the creation of cancer there is. This gene is probably a gene repressive and tumor reducing activities that in the examples of breast cancer, prostate cancer and ovarian cancer have been reported.
protein, FOXP3 herself enzymes, antineoplastic, such as CD8 + and CD39. Hyperactivity CD39 in patients with melanoma, cancer, blood, cancer of the pancreas, colon cancer and ovarian cancer have been reported.
the mutation or disorder in the direction of the regulator Foxp3, leading to the occurrence of diseases autoimmune disease is specific to tissue, such as autoimmune or type 1.
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